Blar i forfatter "Mortensen, Åse-Karen"
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Homology modeling to screen for potential binding of contaminants to thyroid hormone receptor and transthyretin in glaucous gull (Larus hyperboreus) and herring gull (Larus argentatus)
Mortensen, Åse-Karen; Mæhre, Silje; Kristiansen, kurt; Heimstad, Eldbjørg Sofie; Gabrielsen, Geir W.; Jenssen, Bjørn Munro; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-11)Thyroid hormone disrupting chemicals (THDCs) are of major concern in ecotoxicology. With the increased number of emerging chemicals on the market there is a need to screen for potential THDCs in a cost-efficient way, and <i>in silico</i> modeling is an alternative to address this issue. In this study homology modeling and docking was used to screen a list of 626 compounds for potential thyroid hormone ... -
In Vitro and in Silico Competitive Binding of Brominated Polyphenyl Ether Contaminants with Human and Gull Thyroid Hormone Transport Proteins
Hill, Katie L.; Mortensen, Åse-Karen; Teclechiel, Daniel; Willmore, William G.; Sylte, Ingebrigt; Jenssen, Bjørn Munro; Letcher, Robert James (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-28)Tetradecabromo-1,4-diphenoxybenzene (TeDB-DiPhOBz) is a highly brominated additive flame retardant (FR). Debrominated photodegradates of TeDBDiPhOBz are hydroxylated <i>in vitro</i> in liver microsomal assays based on herring gulls (<i>Larus argentatus</i>), including one metabolite identified as 4<i>″</i>-OH-2,2<i>′</i>,2<i>″</i>,4-tetrabromo-DiPhOBz. Chemically related methoxylated tetra- ...